Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population
E Jeannesson, L Albertini, G Siest… - Fundamental & …, 2007 - Wiley Online Library
The ATP‐binding cassette (ABC) transporter ABCB1, or P‐glycoprotein, is a transmembrane
efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 …
efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 …
Ethnicity-Related Polymorphisms and Haplotypes in the Human ABCB1 Gene
C Kimchi-Sarfaty, AH Marple, S Shinar… - …, 2007 - Taylor & Francis
Introduction: The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes
for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer …
for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer …
Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCC2 and their impact on drug disposition
V Haufroid - Current drug targets, 2011 - ingentaconnect.com
The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that
translocate a variety of substrates across extra-and intra-cellular membranes, and act as …
translocate a variety of substrates across extra-and intra-cellular membranes, and act as …
ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?
H Bruckmueller, I Cascorbi - Expert opinion on drug metabolism & …, 2021 - Taylor & Francis
Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …
Simultaneous screening for three mutations in the ABCB1 gene
J Lötsch, C Skarke, G Geisslinger - Genomics, 2003 - Elsevier
A noncoding C3435T mutation in exon 26 of the ABCB1 gene was found to be often
associated with a G2677T (A) mutation in exon 21 encoding an Ala893Ser P-glycoprotein …
associated with a G2677T (A) mutation in exon 21 encoding an Ala893Ser P-glycoprotein …
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature
S Wolking, E Schaeffeler, H Lerche, M Schwab… - Clinical …, 2015 - Springer
ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance
O Bruhn, I Cascorbi - Expert opinion on drug metabolism & …, 2014 - Taylor & Francis
Introduction: Human ATP-binding cassette (ABC) transporters act as translocators of
numerous substrates across extracellular and intracellular membranes, thereby contributing …
numerous substrates across extracellular and intracellular membranes, thereby contributing …
Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications
A Sakurai, A Tamura, Y Onishi… - Expert opinion on …, 2005 - Taylor & Francis
Pharmacogenomics, the study of the influence of genetic factors on drug action, is
increasingly important for predicting pharmacokinetics profiles and/or adverse reactions to …
increasingly important for predicting pharmacokinetics profiles and/or adverse reactions to …
Association of ABCB1 gene polymorphisms with plasma lipid and apolipoprotein concentrations in the STANISLAS cohort
E Jeannesson, G Siest, B Bastien, L Albertini… - Clinica chimica acta, 2009 - Elsevier
BACKGROUND: While involvement of ABCB1 is well known in drug transport, its metabolite
transport role is not so well understood. Like other ABC transporters, ABCB1 might be …
transport role is not so well understood. Like other ABC transporters, ABCB1 might be …
Functional evaluation of ABCB1 (P-glycoprotein) polymorphisms: high-speed screening and structure-activity relationship analyses
T Ishikawa, H Hirano, Y Onishi, A Sakurai… - Drug metabolism and …, 2004 - Elsevier
Evidence is accumulating to strongly suggest that drug transporters are one of the
determinant factors governing the pharmacokinetic profile of drugs. Effort has been made to …
determinant factors governing the pharmacokinetic profile of drugs. Effort has been made to …