[HTML][HTML] Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity
The visceral adipose tissue (VAT) of lean mice hosts a unique population of regulatory T
cells (Tregs) that have a distinct transcriptome and T cell receptor (TCR) repertoire and …
cells (Tregs) that have a distinct transcriptome and T cell receptor (TCR) repertoire and …
[HTML][HTML] Antigen-and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice
D Kolodin, N van Panhuys, C Li, AM Magnuson… - Cell metabolism, 2015 - cell.com
A unique population of Foxp3+ CD4+ regulatory T (Treg) cells, with a distinct transcriptome
and antigen-receptor repertoire, resides in visceral adipose tissue (VAT) of lean individuals …
and antigen-receptor repertoire, resides in visceral adipose tissue (VAT) of lean individuals …
[HTML][HTML] TCR transgenic mice reveal stepwise, multi-site acquisition of the distinctive fat-Treg phenotype
Visceral adipose tissue (VAT) hosts a population of regulatory T (Treg) cells, with a unique
phenotype, that controls local and systemic inflammation and metabolism. Generation of a T …
phenotype, that controls local and systemic inflammation and metabolism. Generation of a T …
[HTML][HTML] Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers
Background The development of insulin resistance (IR) in mouse models of obesity and type
2 diabetes mellitus (DM) is characterized by progressive accumulation of inflammatory …
2 diabetes mellitus (DM) is characterized by progressive accumulation of inflammatory …
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism
SV Torres, K Man, T Elmzzahi, D Malko… - Nature …, 2024 - nature.com
Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic
homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis …
homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis …
Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: Age, diet, and PPARγ effects
D Cipolletta, P Cohen… - Proceedings of the …, 2015 - National Acad Sciences
A unique population of Foxp3+ CD4+ regulatory T (Treg) cells resides in visceral adipose
tissue (VAT) of lean mice, especially in the epididymal fat depot. VAT Tregs are unusual in …
tissue (VAT) of lean mice, especially in the epididymal fat depot. VAT Tregs are unusual in …
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
Y Ilan, R Maron, AM Tukpah… - Proceedings of the …, 2010 - National Acad Sciences
Leptin-deficient ob/ob mice are overweight, develop insulin resistance, and serve as a
model for type 2 diabetes (T2D). Studies suggest that inflammatory pathways are linked to …
model for type 2 diabetes (T2D). Studies suggest that inflammatory pathways are linked to …
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic …
H Yang, YH Youm, B Vandanmagsar… - The Journal of …, 2010 - journals.aai.org
Emerging evidence suggests that increases in activated T cell populations in adipose tissue
may contribute toward obesity-associated metabolic syndrome. The present study …
may contribute toward obesity-associated metabolic syndrome. The present study …
[HTML][HTML] Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets
CE Macdougall, EG Wood, J Loschko, V Scagliotti… - Cell metabolism, 2018 - cell.com
Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy
homeostasis. In addition, VAT is now considered an immune site harboring an array of …
homeostasis. In addition, VAT is now considered an immune site harboring an array of …
[HTML][HTML] A unique population: adipose-resident regulatory T cells
Regulatory T (Treg) cell is well known for its anti-inflammatory function in a variety of tissues
in health and disease. Accordingly, Treg cells that reside in adipose tissue exhibit specific …
in health and disease. Accordingly, Treg cells that reside in adipose tissue exhibit specific …