Disulfiram (DSF) is an FDA approved anti-alcoholism drug in use for more than 60 years.
Recently, antitumor activity of the DSF/copper (DSF/Cu) complex has been identified. Its anti …

Given the huge cost, long research and development (R&D) time and uncertain side effects
of discovering new drugs, drug repositioning of those approved to treat diseases clinically as …

Disulfiram (DSF) chelated with copper has been confirmed to have a strong anti-tumor
ability. In this study, we determined that DSF–Cu induced mitochondria-dependent …

Disulfiram (DSF) has been proved to have broad‐spectrum anti‐alcoholism effects, and it is
also found to show stronger anti‐tumor effects after chelating with Cu2+ to form DSF‐Cu …

Background Disulfiram (DS), an anti-alcoholism drug, demonstrates strong antitumor activity
in a copper (Cu)-dependent manner. This study investigates the cytotoxicity of DS/Cu …

Disulfiram/copper (DSF/Cu) is a promising antitumor reagent for clinical application due to
its excellent anticancer activity and safety. However, the anticancer mechanism of DSF/Cu …

Dithiocarbamate compound Disulfiram (DSF) that binds with copper and functions as an
inhibitor of aldehyde dehydrogenase is a Food and Drug Administration approved agent for …

Background Disulfiram (DSF), a drug widely used to control alcoholism, which has
anticancer activity by inducing apoptosis in a copper (Cu)-dependent manner. Numerous …

Background: Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer
stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram …

Due to its potent anticancer activity, there is interest in repurposing of the FDA-approved anti-
alcoholism drug, disulfiram (DSF). DSF forms potent complexes with copper (DSF/Cu) that …