The mechanisms of drug resistance development in the Plasmodium falciparum parasite to
lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We …

Malaria control is compromised by the development and spread of Plasmodium falciparum
resistance to antimalarial drugs, which has caused an increase in malaria related morbidity …

Background Lumefantrine and mefloquine are used worldwide in artemisinin-based
combination therapy (ACT) of malaria. Better understanding of drug susceptibility and …

Background: The analysis of single nucleotide polymorphism (SNPs) in drug-resistance
associated genes is a commonly used strategy for the surveillance of antimalarial drug …

Background The analysis of single nucleotide polymorphism (SNPs) in drug-resistance
associated genes is a commonly used strategy for the surveillance of anti-malarial drug …

Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …

Background Artemisinin-based combination therapy is the first-line anti-malarial treatment
for uncomplicated Plasmodium falciparum infection in Angola. To date, the prevalence of …

Artemisinin derivative–based combination therapy is expected to suppress the development
of Plasmodium falciparum drug resistance in Africa. We have performed an artemether …

In Uganda, artemether-lumefantrine was introduced as an artemisinin-based combination
therapy (ACT) for malaria in 2006. We have previously reported a moderate decrease in ex …

We evaluated the influence of pfmdr1 mutations and copy number on in vitro artemether and
lumefantrine sensitivity in 101 laboratory and adapted Thai isolates of Plasmodium …