Background Mild cognitive impairment (MCI) represents an at-risk state for Alzheimer's
disease in which underlying pathophysiological mechanisms could be delineated. Oxidative …

Background Extant data from in vivo animal models and postmortem studies indicate that
Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant …

Glutathione (GSH) is a major endogenous antioxidant. Several studies have shown GSH
redox imbalance and altered GSH levels in Alzheimer's disease (AD) patients. Early …

BACKGROUND AND PURPOSE: Oxidative stress has been implicated as an important
pathologic mechanism in the development of Alzheimer disease. The purpose of this study …

Background: Abnormal oxidative stress is an established feature of Alzheimer's disease
(AD). Markers of lipoperoxidation and deficits in serum antioxidants could have a predictive …

[Glutathione in cognitive function and neurodegeneration]. - Abstract - Europe PMC Sign in |
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With millions of older individuals presently suffering from Alzheimer's disease (AD)
worldwide, AD is an unduly common form of dementia that exacts a heavy toll on affected …

Major depression is common in older adults and associated with greater health care
utilisation and increased risk of poor health outcomes. Oxidative stress may be implicated in …

Brain markers of oxidative damage increase with advancing age. In response, brain
antioxidant levels may also increase with age, although this has not been well investigated …

Background Increasing evidence implicates oxidative stress (OS) in Alzheimer disease (AD)
and mild cognitive impairment (MCI). Depletion of the brain antioxidant glutathione (GSH) …