Sphingomylin participates in sperm function in animals, and also regulates the Akt and ERK
signaling pathways, both of which are associated with the asthenospermia. Sphingomyelin …

Abstract Sphingomyelin synthase 2 (SMS2) is an enzyme that catalyzes the conversion of
phosphatidylcholine and ceramide to sphingomyelin and diacylglycerol, and it is crucial to …

Abstract Sphingomyelin synthase 1 (SMS1) and 2 (SMS2) are two enzymes required for
sphingomyelin de novo synthesis, and their roles in tumor transformation and development …

It has been suggested that apoptosis is controlled by two intracellular sphingolipids,
ceramide and sphingosine-1-phosphate (S1P), which are widely distributed in mammalian …

Sphingosine kinase (SPHK) catalyzes sphingosine phosphorylation to form a bioactive lipid
mediator, sphingosine-1-phosphate (S1P). In the current study, we report the presence of …

Deficiency of acid sphingomyelinase (ASM), an enzyme responsible for producing a pro-
apoptotic second messenger ceramide, has previously been shown to promote the survival …

Semenogelin 1 (SEMG1), a main component of human seminal plasma, is a multi-functional
protein involved in the regulation of sperm motility and fertility. SEMG1 is orthologous to …

Sphingomyelin synthase (SMS) is a key enzyme involved in the generation of
sphingomyelin (SM) and regulation of cell growth and survival. However, the effects of SMS …

Objectives Multi-drug resistance (MDR) to chemotherapy is the main obstacle influencing
the anti-tumor effect in breast cancer, which might lead to the metastasis and recurrence of …

Sphingomyelin synthase (SMS) is a membrane enzyme that catalyzes the synthesis of
sphingomyelin, is required for the maintenance of plasma membrane microdomain fluidity …