In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

Introduction: Myocardial infarction (MI) provokes an intense inflammatory response that can
lead to left ventricular adverse remodeling and heart failure (HF). The prognosis of HF …

Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity
related to myocardial infarction is increasing in Western societies. Acute and chronic …

The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …

Endogenous danger signals, or damage-associated molecular patterns (DAMPs), are
generated in response to cell stress and activate innate immunity to provide a pivotal …

One of the major therapeutic challenges in the arena of interventional cardiology is to design
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …

Myocardial ischemia/reperfusion (I/R) is the most common cause of myocardial
inflammation, which is primarily a manifestation of the innate immune responses. Innate …

Cardiac fibroblasts (CF) are well-established as key regulators of extracellular matrix (ECM)
turnover in the context of myocardial remodelling and fibrosis. Recently, this cell type has …

Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Acute cardiomyocyte necrosis in the infarcted heart generates damage‐associated
molecular patterns (DAMP s), activating complement and T oll‐L ike R eceptor …