Background Gene fusions represent promising targets for cancer therapy in lung cancer.
Reliable detection of multiple gene fusions is therefore essential. Methods Five …

Gene fusions have a pivotal role in non-small cell lung cancer (NSCLC) precision medicine.
Several techniques can be used, from fluorescence in situ hybridization and …

Molecular profiling of non‐small cell lung cancers (NSCLC) has a strong impact on clinical
decision making and current oncological therapies. Besides detection of activating …

Gene fusions are important genomic events in human cancer because their fusion gene
products can drive the development of cancer and thus are potential prognostic tools or …

Cancer genomes contain many aberrant gene fusions—a few that drive disease and many
more that are nonspecific passengers. We developed an algorithm (the concept signature …

In cancer, fusions are important diagnostic markers and targets for therapy. Long-read
transcriptome sequencing allows the discovery of fusions with their full-length isoform …

Analysis of fusion transcripts has become increasingly important due to their link with cancer
development. Since high-throughput sequencing approaches survey fusion events …

Motivation: Paired-end whole transcriptome sequencing provides evidence for fusion
transcripts. However, due to the repetitiveness of the transcriptome, many reads have …

Motivation: Next generation sequencing technology generates high-throughput data, which
allows us to detect fusion genes at both transcript and genomic levels. To detect fusion …

FusionCatcher is a software tool for finding somatic fusion genes in paired-end RNA-
sequencing data from human or other vertebrates. FusionCatcher achieves competitive …