Oral administration of insulin remains a challenge due to its poor enzymatic stability and
inefficient permeation across epithelium. We herein developed a novel self-assembled …

The present study was to demonstrate the effects of goblet cell-targeting nanoparticles on
the oral absorption of insulin in vitro, ex vivo and in vivo, and identify the targeting …

The effect of nanoparticulate delivery system on enhancing insulin permeation through
intestinal membrane was evaluated in different intestinal epithelial models using cell …

Oral protein drug delivery using nano-based systems remains challenging, as contradictory
surface properties are required for efficient navigation through the intestinal mucus and …

Mucoadhesive and mucopenetrating nanoparticles are commonly designed to improve
mucosal drug delivery efficiency. Herein, in order to better understand the contribution of …

The oral delivery of macromolecules using nanoparticles is limited by secreted mucus,
resulting in low contact or internalization via intestinal cells and, thus, both mucus trapping …

Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can
efficiently overcome the absorption barriers of mucosa tissue, which consists of not only …

Despite advances in drug-delivery technologies, successful oral administration of protein
drugs remains an elusive challenge. When protein drugs are administered orally, they can …

Intestinal uptake, insulinemia and hypoglycemic effect of orally delivered insulin
encapsulated in polyelectrolytically stable nanoparticles were evaluated in streptozotocin …

The oral route is the best way to administer a drug; however, fitting peptide drugs in this
route is a major challenge. In insulin cases, less than 0.5% of the administered dose …