Long non‐coding RNAs in cancer: another layer of complexity

JC de Oliveira, LC Oliveira, C Mathias… - The journal of gene …, 2019 - Wiley Online Library
We review the most well characterized long non‐coding RNAs (lncRNAs) with important
roles in hallmarks of cancer, additionally including lncRNAs with a higher potential for …

LncRNAs and neoplasia

M Isin, N Dalay - Clinica chimica acta, 2015 - Elsevier
Long noncoding RNAs are emerging as new mediators of tumorigenesis by virtue of their
various functions and their capacity to induce different mechanisms as a result of their wide …

Long noncoding RNA and cancer: a new paradigm

A Bhan, M Soleimani, SS Mandal - Cancer research, 2017 - AACR
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

Long non-coding RNAs involved in gynecological cancer

M Zhao, Y Qiu, B Yang, L Sun, K Hei, X Du… - International Journal of …, 2014 - ijgc.bmj.com
Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides
with little or no protein-coding capacity. Previously, they were considered transcription …

Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets

R Fatima, VS Akhade, D Pal, SMR Rao - Molecular and cellular therapies, 2015 - Springer
Long noncoding RNAs are emerging as key players in various fundamental biological
processes. We highlight the varied molecular mechanisms by which lncRNAs modulate …

Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers

N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis

S Najafi, SH Khatami, M Khorsand, Z Jamali… - Experimental cell …, 2022 - Elsevier
New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a
broad range of biological processes, including the pathogenesis of many complex human …

The regulatory role of long noncoding RNAs in cancer

Y Tang, BB Cheung, B Atmadibrata, GM Marshall… - Cancer letters, 2017 - Elsevier
With the advances in genomic analysis technologies, especially next-generation RNA
sequencing, a large number of new transcripts have been discovered, leading to better …

[HTML][HTML] Potential impact and mechanism of Long Non-coding RNAs on cancer and associated T cells

W Chen, S Liu, F Wang - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
The discovery of many aberrant expressions of long non-coding RNAs (lncRNAs) in various
cancers has focused attention on the effects of lncRNA on cancer cells themselves …

Long noncoding RNAs and tumorigenesis: genetic associations, molecular mechanisms, and therapeutic strategies

F Zhang, L Zhang, C Zhang - Tumor Biology, 2016 - Springer
The human genome contains a large number of nonprotein-coding sequences. Recently,
new discoveries in the functions of nonprotein-coding sequences have demonstrated that …