The tumor microenvironment (TME) consists of cancer cells that interact with stromal
components such as the extracellular matrix, blood, and lymphatic networks, fibroblasts …

The tumor microenvironment (TME) may be best conceptualized as an ecosystem
comprised of cancer cells interacting with a multitude of stromal components such as the …

As one of the important cancer hallmarks, metabolism reprogramming, including lipid
metabolism alterations, occurs in tumor cells and the tumor microenvironment (TME). It plays …

In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-
phosphate (S1P) and both normal physiology and progression of different diseases …

Immunotherapy is now considered an innovative and strong strategy to beat metastatic, drug-
resistant, or relapsing tumours. It is based on the manipulation of several mechanisms …

The sphingolipid sphingosine-1-phosphate (S1P) promotes tumor development through a
variety of mechanisms including promoting proliferation, survival, and migration of cancer …

The effects of lysophospholipids (LPLs) on cancer microenvironment is a vast and growing
field. These lipids are secreted physiologically by various cell types. They play highly …

CD8 T lymphocytes are able to eliminate nascent tumor cells through a process referred to
as immunosurveillance. However, multiple inhibitory mechanisms within the tumor …

Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine
signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing …

Abstract Sphingosine-1-phosphate (S1P), together with other phosphosphingolipids, has
been found to regulate complex cellular function in the tumor microenvironment (TME) …