Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid
malignancies, with a five-year survival rate of only~ 10%. Pancreatic tissue becomes …

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis
calls for a more detailed understanding of disease biology in order to pave the way for the …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …

The stroma-rich, immunosuppressive microenvironment is a hallmark of pancreatic ductal
adenocarcinoma (PDA). Tumor cells and other cellular components of the tumor …

Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …

Simple Summary Pancreatic cancer is a highly malignant disease with treatment resistance
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …

Pancreatic adenocarcinoma is a highly lethal disease that is histologically characterized by
a dense desmoplastic reaction (DR) surrounding malignant epithelial cells. The DR is …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is the most common form of
pancreatic tumours, representing greater than 90% of all diagnosed cases of pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a five-year
survival rate of only 9%. PDAC is characterized by a dense, fibrotic stroma composed of …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly
desmoplastic and extreme immunosuppressive tumor microenvironment (TME), which …