Nature-inspired, bridged polycyclic molecules share low similarity with currently available
drugs, containing preferentially planar and/or achiral moieties. This “Escape from Flatland” …

The complexity of neurodegenerative diseases, among which Alzheimer's disease plays a
pivotal role, poses one of the tough therapeutic challenges of present time. In this …

Aim: Simultaneous modulation of several key targets of the pathological network of
Alzheimer's disease (AD) is being increasingly pursued as a promising option to fill the …

Seven-membered nitrogen heterocycles have a strong influence in drug discovery due to
their inherent 3D character, which allows the ability to explore a vast conformational space …

Multitarget drug discovery is one of the hottest topics and most active fields in the search for
new molecules against Alzheimer's disease (AD). Over the last 20 years, many promising …

Overcoming the lack of effective treatments and the continuous clinical trial failures in
neurodegenerative drug discovery might require a shift from the prevailing paradigm …

Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder that
slowly destroys memory. The precise mechanism of AD is still not entirely understood and …

We have synthesized a family of rhein–huprine hybrids to hit several key targets for
Alzheimer's disease. Biological screening performed in vitro and in Escherichia coli cells …

Polycyclic cage scaffolds have been successfully used in the development of numerous lead
compounds demonstrating activity in the central nervous system (CNS). Several …

Abstract Tetrahydrospiro [1, 3-dioxolane-2, 1′-pentalen]-4′-ones were stereoselectively
converted to either (cis, anti, cis)-or (cis, syn)-linear dodecahydrocyclopenta [a] indene …