Advances in Chlamydia trachomatis Vaccination: Unveiling the Potential of Major Outer Membrane Protein Derivative Constructs

C Kiekens, SA Morré, D Vanrompay - Microorganisms, 2024 - mdpi.com
Chlamydia (C.) trachomatis, a leading cause of sexually transmitted infections (STIs)
worldwide, continues to be a significant public health concern. The majority of infections are …

Recombinant expression of Chlamydia trachomatis major outer membrane protein in E. Coli outer membrane as a substrate for vaccine research

Z Wen, MA Boddicker, RM Kaufhold, P Khandelwal… - BMC microbiology, 2016 - Springer
Background Chlamydia trachomatis is a human pathogen which causes a number of
pathologies, including genital tract infections in women that can result in tubal infertility …

Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen

R Hadad, E Marks, I Kalbina, K Schön, M Unemo… - APMIS, 2016 - Wiley Online Library
The asymptomatic nature of most Chlamydia trachomatis infections and the lack of
appropriate effects by current prevention and management call for vaccine development. We …

Subunit vaccines for the prevention of mucosal infection with Chlamydia trachomatis

H Yu, KP Karunakaran, X Jiang… - Expert review of …, 2016 - Taylor & Francis
Chlamydia trachomatis is the most common preventable cause of tubal infertility in women.
In high-income countries, despite public health control efforts, C. trachomatis case rates …

[HTML][HTML] Seventy years of Chlamydia vaccine research–limitations of the past and directions for the future

S Phillips, BL Quigley, P Timms - Frontiers in microbiology, 2019 - frontiersin.org
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of
animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only …

Towards A Chlamydia Trachomatis Vaccine: How Close Are We?

M Cochrane, CW Armitage, CP O'Meara… - Future …, 2010 - Taylor & Francis
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections and
preventable blindness worldwide. The incidence of chlamydial sexually transmitted …

Structural and immunological characterization of novel recombinant MOMP-based chlamydial antigens

G Madico, O Gursky, J Fairman, P Massari - Vaccines, 2017 - mdpi.com
Chlamydia is the most common cause of bacterial sexually transmitted infections worldwide.
While infections resolve with antibiotic treatment, this is often neglected in women due to …

Considerations for the rational design of a Chlamydia vaccine

S Liang, D Bulir, C Kaushic… - Human vaccines & …, 2017 - Taylor & Francis
Chlamydia trachomatis is the leading cause of preventable blindness and the most common
bacterial sexually transmitted infection. Remarkable progress in vaccine research over the …

Development status and future prospects for a vaccine against Chlamydia trachomatis infection

LM Hafner, DP Wilson, P Timms - Vaccine, 2014 - Elsevier
Chlamydia trachomatis continues to be the most commonly reported sexually transmitted
bacterial infection in many countries with more than 100 million new cases estimated …

Protection against a chlamydial respiratory challenge by a chimeric vaccine formulated with the Chlamydia muridarum major outer membrane protein variable domains using the …

DF Tifrea, S Pal, J Fairman, P Massari, LM de La Maza - npj Vaccines, 2020 - nature.com
Chlamydia trachomatis is the most frequently detected sexually transmitted bacterial
pathogen in the world. Attempts to control these infections with screening programs and …