How to select firefly luciferin analogues for in vivo imaging

R Saito-Moriya, J Nakayama, G Kamiya… - International Journal of …, 2021 - mdpi.com
Bioluminescence reactions are widely applied in optical in vivo imaging in the life science
and medical fields. Such reactions produce light upon the oxidation of a luciferin (substrate) …

Multicolor bioluminescence obtained using firefly luciferin

M Kiyama, R Saito, S Iwano, R Obata… - Current Topics in …, 2016 - ingentaconnect.com
Firefly bioluminescence is widely used in life science research as a useful analysis tool. For
example, the adenosine-5′-triphosphate (ATP)-dependent enzymatic firefly …

Constructing firefly luciferin bioluminescence probes for in vivo imaging

X Yang, X Qin, H Ji, L Du, M Li - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
Bioluminescence imaging (BLI) is a widely applied visual approach for real-time detecting
many physiological and pathological processes in a variety of biological systems. Based on …

Brominated luciferins are versatile bioluminescent probes

RC Steinhardt, CM Rathbun, BT Krull, JM Yu… - …, 2017 - Wiley Online Library
We report a set of brominated luciferins for bioluminescence imaging. These regioisomeric
scaffolds were accessed by using a common synthetic route. All analogues produced light …

Cage the firefly luciferin!–a strategy for developing bioluminescent probes

J Li, L Chen, L Du, M Li - Chemical Society Reviews, 2013 - pubs.rsc.org
Bioluminescent imaging (BLI) has been widely applicable in the imaging of process
envisioned in life sciences. As the most conventional technique for BLI, the firefly luciferin …

Activity‐Based Luciferase‐Luciferin Bioluminescence System for Bioimaging Applications

T Xia, X Cheng, W Zhan, G Liang - Analysis & Sensing, 2021 - Wiley Online Library
There is growing interest in applying bioluminescence for imaging varies biological
processes in life sciences due to its high resolution, selectivity, and signal/noise ratio (no …

Beyond luciferase-luciferin system: Modification, improved imaging and biomedical application

Y Jiang, X Shi, C Tang, F Wang - Coordination Chemistry Reviews, 2023 - Elsevier
The bioluminescence signal generated by the luciferase-luciferin interaction, exploited for
real-time and continuous monitoring of numerous biochemical processes in living cells and …

[HTML][HTML] Emerging tools for bioluminescence imaging

G Zambito, C Chawda, L Mezzanotte - Current Opinion in Chemical Biology, 2021 - Elsevier
Bioluminescence (BL) relies on the enzymatic reaction between luciferase, a substrate
conventionally named luciferin, and various cofactors. BL imaging has become a widely …

Bioluminescent probes for imaging biology beyond the culture dish

CM Rathbun, JA Prescher - Biochemistry, 2017 - ACS Publications
Bioluminescence with luciferase–luciferin pairs is an attractive method for surveying cells in
live tissues and whole organisms. Recent advances in luciferin chemistry and luciferase …

Rapid and scalable assembly of firefly luciferase substrates

DC McCutcheon, WB Porterfield… - Organic & biomolecular …, 2015 - pubs.rsc.org
Bioluminescence imaging with luciferase–luciferin pairs is a popular method for visualizing
biological processes in vivo. Unfortunately, most luciferins are difficult to access and remain …