Abstract Background: P-glycoprotein (gp170; encoded by the MDR1 gene [also known as
PGY1]) is a membrane protein capable of exporting a variety of anticancer drugs from cells …

: Background: Resistance to drugs with different structure and function is a great obstacle to
the successful treatment of breast cancer. A well-known mechanism responsible for drug …

Chemotherapy has been used widely to treat cancer, both as a systemic therapy and as a
local treatment. Unfortunately, many types of cancer are still refractory to chemotherapy. The …

Several studies have investigated the association between multidrug resistance gene
(MDR1) C1236T polymorphism and leukemia risk, however, these published studies have …

11010 Background: The clinical significance of MDR1 as a mechanism of multidrug
resistance in breast cancer has not been established. We conducted a meta-analysis …

Abstract Background and Aims: Host genetic factors play a key role in gastric
carcinogenesis, but the mechanism has not been clarified. The multi‐drug resistance 1 …

Introduction The multidrug resistance 1 (MDR1) gene plays an important function in
carcinogens detoxification and drugs metabolism. Many authors reported that MDR1 gene …

The objective of this study was to examine associations of single nucleotide polymorphisms,
rs1045642 within the MDR1 gene and rs1799930 within the NAT2 gene, with the risk of …

A possible association between multiple drug resistance 1 gene (MDR1) polymorphisms
and the risk of developing hepatocellular carcinoma (HCC) is currently under debate, and …

The human multidrug resistance MDR1 gene plays a crucial role in the absorption, transport,
metabolism and elimination of harmful compounds. An impaired metabolism of these …