Aim: Over-expression of some genes, such as MDR1, can increase the level of
chemotherapy drug afflux and limit the effectiveness of treatment. We aimed to investigate …

Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1
gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was …

We read with great interest a recent article entitled ''Association between two polymorphisms
of ABCB1 and breast cancer risk in the current studies: a meta-analysis''by Lu et al.[1] …

Objective A relationship between polymorphisms rs1128503 and rs1045642 in the multidrug
resistance 1 gene (MDR1) and susceptibility to hepatocellular carcinoma (HCC) has been …

Primary chemotherapy is a useful strategy for the treatment of locally advanced breast
cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the …

In first part of this study, a systematic review was designed to explore the involvement of
CYP1A1 and GSTP1 genes in breast cancerogenesis. Based on systematic review, we …

The objective of this study was to evaluate the influence of c. 1564A> T genetic
polymorphisms in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma …

Background Functional variants of the xenobiotic-metabolizing genes (XMG) might modulate
breast cancer (BC) risk by altering the rate of metabolism and clearance of myriad types of …

Background: Multiple drug resistance presents a major problem for successful cancer
chemotherapy. One of the most important proteins contributing to the development of …

The association of CYP19 gene polymorphisms with breast cancer has been widely
reported, but results of previous studies were somewhat contradictory and underpowered. In …