The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing
susceptibility to hepatocellular carcinoma (HCC). The objective of the present study was to …

Previous epidemiological studies have evaluated the association between the ABCB1
polymorphism and the risk of breast cancer with conflicting results. Hence, we conducted a …

Abstract Background The CYP1B1 gene is a polymorphic member of the P450 gene family
and is considered to be a candidate gene for cancers of various types. Objective We …

Objective: To evaluate the impact of the multi-drug resistance 1 (MDR1) C3435T
polymorphism on clinical outcomes in gastric cancer patients treated with postoperative …

The human multidrug‐resistance (MDR1) gene encodes an integral cell membrane protein,
P‐glycoprotein (PGP), which generates the ATP‐dependent cellular transport of substances …

Introduction Chemotherapy is the standard and recommended treatment for lung cancer
apart from surgery and radiotherapy. Chemotherapy is administered as mono-agents or as …

Objective The P-glycoprotein, a product of MDR1 (multiple drug resistance 1) gene, is a
membrane efflux pump localized in epithelial cells in the small and large intestine, a part of …

The human multidrug resistance (MDR1, ABCB1) gene encodes P-glycoprotein (P-gp),
which affects the pharmacokinetics of many drugs. Polymorphisms in ABCB1 might …

Purpose: Activation of the MDR1 upstream promoter (USP) has been described previously
in four lymphoblastic leukemia patients, where it is the major MDR1 promoter associated …

Background The human multi-drug resistance gene (MDR1), which encodes the major trans-
membrane transporter P-glycoprotein (P-gp), was found to be associated with susceptibility …