DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …

GOMEZ, Rodolfo et al. DNA methylation analysis identifies key transcription factors involved
in mesenchymal stem cell osteogenic differentiation. Biol. Res.[online]. 2023, vol. 56, 9 …

Altered DNA methylation upon ageing may result in many age‐related diseases such as
osteoporosis. However, the changes in DNA methylation that occur in cortical bones, the …

Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–
environment interactions, and their role in disease pathogenesis. Blood is an obvious …

Bone marrow mesenchymal stem cells (BMSCs) nowadays are regarded as promising
candidates in cell‐based therapy for the regeneration of damaged bone tissues that are …

Objective To determine genome‐wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …

The role and underlying mechanisms of DNA methylation in osteogenesis/chondrogenesis
remain poorly understood. We here reveal DNA methyltransferase 1 (DNMT1), which is …

Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic
mechanisms including DNA methylation. Methylation changes may also play a key role in …

DNA methylation in eukaryotes invokes heritable alterations of the of the cytosine base in
DNA without changing the underlying genomic DNA sequence. DNA methylationmay be …

Epigenetic modifications are heritable changes in gene expression without changes in DNA
sequence. DNA methylation has been implicated in the control of several cellular processes …