Osteoarthritis is one of the most prevalent chronic joint diseases for middle-aged and elderly
people. But in recent years, the number of young people suffering from the disease …

Despite advanced understanding of signaling mediated by local and systemic factors, the
role of epigenetic factors in the regulation of bone regeneration remains vague. The DNA …

Objectives Epigenetic mechanisms influence the development and maintenance of complex
phenotypes and may also contribute to the evolution of species–specific phenotypes. With …

DNA methylation profile, consisting of tissue‐dependent and differentially methylated
regions (T‐DMRs), has elucidated tissue‐specific gene function in mouse tissues. Here, we …

Background Cancer cells undergo massive alterations to their DNA methylation patterns that
result in aberrant gene expression and malignant phenotypes. However, the mechanisms …

DNA methylation has been proved to play important roles in cell development and complex
diseases through comparative studies of DNA methylation profiles across different tissues …

Chromatin modifying enzymes play essential roles in skeletal development and bone
maintenance, and deregulation of epigenetic mechanisms can lead to skeletal growth and …

Background DNA methylation has been recognized as a key mechanism in cell
differentiation. Various studies have compared tissues to characterize epigenetically …

Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …

DNA methylation has emerged as a crucial regulator of chondrocyte dedifferentiation, which
severely compromises the outcome of autologous chondrocyte implantation (ACI) treatment …