Archaeobacterial ether lipid liposomes (archaeosomes) as novel vaccine and drug delivery systems

GB Patel, GD Sprott - Critical reviews in biotechnology, 1999 - Taylor & Francis
Liposomes are artificial, spherical, closed vesicles consisting of one or more lipid bilayer (s).
Liposomes made from ester phospholipids have been studied extensively over the last 3 …

Safety of archaeosome adjuvants evaluated in a mouse model

GB Patel, A Omri, L Deschatelets… - Journal of Liposome …, 2002 - Taylor & Francis
Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea,
demonstrate great potential as immunomodulating carriers of soluble antigens, promoting …

Archaeosome immunostimulatory vaccine delivery system

GB Patel, W Chen - Current drug delivery, 2005 - ingentaconnect.com
Archaeosomes are liposomes made from the polar ether lipids of Archaea. These lipids are
unique and distinct in structure from the ester lipids found in Eukarya and Bacteria. The …

Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum

L Krishnan, CJ Dicaire, GB Patel… - Infection and …, 2000 - Am Soc Microbiol
Ether glycerolipids extracted from various archaeobacteria were formulated into liposomes
(archaeosomes) possessing strong adjuvant properties. Mice of varying genetic …

Short-term repeated-dose toxicity profile of archaeosomes administered to mice via intravenous and oral routes

A Omri, BJ Agnew, GB Patel - International journal of …, 2003 - journals.sagepub.com
Archaeosomes, liposomes made from polar ether lipids of archaea, show promise for
vaccine and drug delivery applications. The potential toxicity of intravenously (14, 70, or 140 …

New generation of liposomes called archaeosomes based on natural or synthetic archaeal lipids as innovative formulations for drug delivery

T Benvegnu, L Lemiègre… - Recent patents on drug …, 2009 - ingentaconnect.com
Archaeosomes made from natural archaeal membrane lipids and/or synthetic lipid
analogues have been extensively studied for potential applications in drug and vaccine …

A comparison of the immune responses induced by antigens in three different archaeosome-based vaccine formulations

Y Jia, B Akache, L Deschatelets, H Qian… - International journal of …, 2019 - Elsevier
Archaeosomes are liposomes composed of natural or synthetic archaeal lipids that can be
used as adjuvants to induce strong long-lasting humoral and cell-mediated immune …

Stability of pressure-extruded liposomes made from archaeobacterial ether lipids

CG Choquet, GB Patel, GD Sprott… - Applied microbiology and …, 1994 - Springer
Ether lipids were obtained from a wide range of archaeobacteria grown at extremes of pH,
temperature, and salt concentration. With the exception of Sulfolobus acidocaldarius …

Archaeosomes: an excellent carrier for drug and cell delivery

G Kaur, T Garg, G Rath, AK Goyal - Drug delivery, 2016 - Taylor & Francis
Archaeosomes as liposomes made with one or more ether lipids that are unique to the
domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean …

Stability of liposomes prepared from archaeobacterical lipids and phosphatidylcholine mixtures

GD Sprott, CJ Dicaire, LP Fleming… - Cells and …, 1996 - digitalcommons.usu.edu
In vitro stabilities of liposomes prepared from the total polar lipids (TPL) of various species of
Archaeobacteria were compared with those made from egg phosphatidylcholine (EPC) and …