The ability to directly manipulate the pig genome through genetic engineering has been
available to the research community for over three decades. This technology has …

Genetic modification of animals via selective breeding is the basis for modern agriculture.
The current breeding paradigm however has limitations, chief among them is the …

Genetically modified animals, especially rodents, are widely used in biomedical research.
However, non-rodent models are required for efficient translational medicine and preclinical …

Germline editing, the process by which the genome of an individual is edited in such a way
that the change is heritable, has been applied to a wide variety of animals [DA Sorrell, AF …

The first genetically modified large animals were generated in 1985 by microinjection to
increase the growth of agricultural livestock such as pigs (1). Since then, it has been a …

This issue of Animal Frontiers,“Farm animals are important biomedical models,” describes
several examples in which cattle, sheep, pigs, or chickens provide an excellent …

Over the past 5 years there has been a major transformation in our ability to precisely
manipulate the genomes of animals. Efficiencies of introducing precise genetic alterations in …

• Methods for genome editing have developed over the past decades, making the
technology more efficient and specific.• Technology to generate edited pigs and chickens is …

Pigs serve as an important agricultural resource and animal model in biomedical studies.
Efficient and precise modification of pig genome by using recently developed gene editing …

Animal models, particularly pigs, have come to play an important role in translational
biomedical research. There have been many pig models with genetically modifications via …