The intestinal mucus gel layer represents a stumbling block for drug adsorption. This study is
aimed to formulate a nanoparticulate system able to overcome this barrier by cleaving …

The aim of the present study was to develop a novel nanoparticulate delivery system being
capable of penetrating the intestinal mucus layer by cleaving mucoglycoprotein …

Particle diffusion through the intestinal mucosal barrier is restricted by the viscoelastic and
adhesive properties of the mucus gel layer, preventing their penetration to the underlying …

The effectiveness of delivering oral therapeutic peptides, proteins and nucleotides is often
hindered by the protective mucus barrier that covers mucosal surfaces of the gastrointestinal …

Nanoparticles have opened a new perspective for oral drug delivery. However, nanoparticle
transport is strongly hindered by mucus and epithelial barriers before they can enter the …

Mucus is a viscoelastic hydrogel that lubricates and protects mucosal tissues such as the
eyes, lung, gastrointestinal tract, and vagina. Nanoparticle-based drug delivery systems …

The use of nanoparticles (NPs) can improve drug delivery in many pharmaceutical
applications. Compared to conventional compounds, NPs are expected to show better tissue …

The aim of this study was to develop and evaluate a novel mucoadhesive drug delivery
system based on thiolated poly (acrylic acid) nanoparticles exhibiting mucolytic properties to …

The present review provides an overview of nanotechnology-based strategies to overcome
various mucus gel barriers including the intestinal, nasal, ocular, vaginal, buccal and …

Aim The aim of this study was to evaluate the potential of chitosan/tripolyphosphate (TPP)
nanoparticles to provide a targeted release of β-galactosidase behind the intestinal mucus …