SIRT1, a member of the sirtuin family, belongs to the NAD+-dependent class III histone
deacetylase. SIRT1 can regulate gene expression by catalyzing non-histone and histone …

Sirtuin 1 (SIRT1), the mammalian Sir2 homologue, is a class III histone deacetylase shown
to act on a wide range of histones and non-histone substrates. Numerous studies have …

The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

Sepsis, a dysregulated host response to infection, is a major public health concern. Though
experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis …

Sepsis and septic shock are the leading causes of death in non-coronary intensive care
units worldwide. During sepsis-associated immune dysfunction, the early/hyper …

Sepsis is a life-threatening organ dysfunction caused by the host's dysfunctional response to
infection. Abnormal activation of the immune system and disturbance of energy metabolism …

Acute and chronic inflammations are key homeostatic events in health and disease. Sirtuins
(SIRTs), a family of NAD-dependent protein deacylases, play a pivotal role in the regulation …

Background: Seven isoforms of histone deacetylase Class III have been reported-Sirtuin
(SIRT) 1-7. We recently demonstrated that EX-527, an inhibitor of SIRT1, reduces mortality in …

Sepsis is a systemic inflammatory response resulting from the excessive production of pro-
inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively …

Obesity increases morbidity and mortality in acute illnesses such as sepsis and septic shock.
We showed previously that the early/hyper-inflammatory phase of sepsis is exaggerated in …