Context DNA methylation has been identified among putative regulatory mechanisms for
CYP11B2 expression in primary aldosteronism. Objective The objective of this work is to …

The purpose of this study was to evaluate the DNA methylation levels of steroidogenic
enzyme genes in aldosterone-producing adenoma (APA) and the effects of gene mutations …

Objective The pathophysiology of aldosterone-producing adenomas (APA) has been
investigated intensively through genetic and genomic approaches. However, the role of …

Objective: Our objective was to determine whether any changes in methylation are
associated with aldosteronomas. Methods: We performed integrated genome-wide …

Adrenocortical hormone excess, due to primary aldosteronism (PA) or hypercortisolemia,
causes hypertension and cardiovascular complications. In PA, hypomethylation of …

Context Aldosterone production is stimulated by activation of calcium signaling in
aldosterone-producing adenomas (APAs), and epigenetic factors such as DNA methylation …

DNA methylation is associated with excess cortisol and aldosterone. The DNA encoding
aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1), which catalyzes the …

Background DNA methylation is believed to be maintained in adult somatic cells. Recent
findings, however, suggest that all methylation patterns are not stable. We demonstrate that …

1) Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama 222-0036,
Japan 2) Department of Pathology, Tohoku University Graduate School of Medicine, Sendai …

Abstract Introduction Cytochrome P450 11B2 (CYP11B2) plays a pivotal role in aldosterone
synthesis, while cytochrome P450 11B1 (CYP11B1) and cytochrome P450 17A1 (CYP17) …