In chronic hepatitis B (CHB) and C (CHC) infections, the composition of the immune cell
microenvironment at the site of infection is poorly understood. Thus, our aim was to …

Summary In Chronic hepatitis B (CHB) infection, virus and immune response interplay is
thought to be responsible for pathogenesis. Yet, the impact of each immune cell population …

Aim: To evaluate the immune response in peripheral blood and liver tissue, through the
measurement of T-cell subsets, in patients with chronic hepatitis B (CHB) and C (CHC) …

BACKGROUND & AIMS: The cytokine pattern secreted by T cells at the site of viral
replication may influence the final outcome of hepatitis B virus (HBV) and hepatitis C virus …

Abstract Background Hepatitis B virus (HBV) replicates non-cytopathically in the hepatocytes
and HBV-related diseases are caused by immune-mediated inflammatory events. This study …

Results Among lymphocyte subsets analyzed, CD45RA+ CD62L+ subsets were significantly
lower in HBV-infected livers than in healthy controls. Intrahepatic naive lymphocytes was …

Cytokine balance may play an important role in effective antiviral immunity. We determined
the frequencies of interferon-γ (IFN-γ)-, interleukin-4 (IL-4)-, and interleukin-10 (IL-10) …

Cytotoxic T lymphocytes (CTL) and Kupffer cells play an important role in the immune control
of hepatitis B virus (HBV), but may also induce liver injury during infection. We investigated …

Cytokines released by infiltrating T cells may contribute to the hepatic injury in chronic
hepatitis. Therefore, we characterized peripheral blood‐and liver‐infiltrating T cells from …

Hepatitis B virus (HBV)‐specific T cells play a key role in clearance of the virus and in the
pathogenesis of liver disease. Peripheral blood (n= 25) and liver biopsies (n= 19) were …