Gynecological malignancy seriously threatens the physical and mental health of women.
Shikonin is a naphthoquinone compound with a variety of biological activities. Studies have …

In this study, a series of novel shikonin derivatives (30–49) were designed and synthesized
and their anti-proliferative activities were evaluated against five different cancer cell lines …

Shikonin has previously been reported to function as a potent anti-cancer drug that induces
cell apoptosis via diverse pathways. To optimize the effectiveness of its pro-apoptotic …

Shikonin is the major bioactive component extracted from the roots of Lithospermum
erythrorhizon which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent …

Shikonin is one of the major bioactive components of Lithospermum erythrorhizon. It has a
good killing effect in a variety of tumor cells. Its antitumor effect involves multiple targets and …

Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in
the drug discovery and development of anticancer agents. Despite having numerous …

Triple-negative breast cancer (TNBC) has an unfavorable prognosis attribute to its low
differentiation, rapid proliferation and high distant metastasis rate. PI3K/Akt/mTOR as an …

Cervical cancer is one of the most lethal malignancies of the female reproductive system.
Shikonin, a naphthoquinone pigment extracted from the traditional medicinal herb …

Shikonin is a natural compound isolated from herbs and traditional medicines that have
been used in a number of countries to treat various illnesses including inflammation, virus …

The present study identified that shikonin, a naphthoquinone extracted from the roots of
Lithospermum erythrorhizon, inhibits the migration of ovarian cancer cells and induces their …