Hepatocellular carcinoma (HCC) is the second most common cancer worldwide,
demonstrating aggressiveness and mortality more frequently in men than in women. Despite …

Hepatocellular carcinoma (HCC) is the common primary liver cancer and the third leading
cause of cancer related mortality worldwide. It is generally thought that the estrogen …

The incidence of hepatocellular carcinoma (HCC) is significantly lower in women than men,
implying that estrogen receptors (ERs) may play an important role in this sex dimorphism …

Background & Aims Aberrant estrogen receptor-α (ERα) expression and signaling are
implicated in the development of hepatocellular carcinoma (HCC), but its regulation in HCC …

Hepatocellular carcinoma (HCC) is an aggressive malignancy with a poor prognosis.
Effective biomarkers and specific therapeutic targets for HCC are therefore urgently needed …

Background Although expression of MTA1 inversely correlates with the nuclear localization
of ERα, the effect and molecular mechanism of ERα regulation of MTA1 remain unknown …

Background Epidermal growth factor (EGF) signaling is implicated in the invasion and
metastasis of hepatoma cells. However, the signaling pathways for EGF-induced motility of …

Epidemiological studies and experimental data have shown that the incidences of
hepatocellular carcinoma in men are more frequent than in women. Evidence suggests that …

EGR1 plays a critical role in cancer progression. However, its precise role in hepatocellular
carcinoma has not been elucidated. In this study, we found that the overexpression of EGR1 …

Estrogen (E2) has been suggested to have a protective role in attenuating hepatocellular
carcinoma (HCC) development. miRNAs have great potential as biomarkers and therapeutic …