Characterization of the human myocardial proteome in inflammatory dilated cardiomyopathy by label-free quantitative shotgun proteomics of heart biopsies

E Hammer, M Goritzka, S Ameling, K Darm… - Journal of proteome …, 2011 - ACS Publications
Dilated cardiomyopathy (DCM) is characterized by contractile dysfunction leading to heart
failure. The molecular changes in the human heart associated with this disease have so far …

Proteomics in heart failure: top-down or bottom-up?

ZR Gregorich, YH Chang, Y Ge - Pflügers Archiv-European Journal of …, 2014 - Springer
The pathophysiology of heart failure (HF) is diverse, owing to multiple etiologies and
aberrations in a number of cellular processes. Therefore, it is essential to understand how …

Predicting left ventricular remodeling after a first myocardial infarction by plasma proteome analysis

F Pinet, O Beseme, C Cieniewski‐Bernard… - …, 2008 - Wiley Online Library
Recent improvements in therapeutic strategies did not prevent left ventricular remodeling
(LVR), which remains a common event (30%) after acute myocardial infarction (AMI). We …

Using peripheral blood mononuclear cells to determine proteome profiles in human cardiac failure

A Mazzola, R Cianti, L Bini, A Armini… - European journal of …, 2008 - Wiley Online Library
Background: In chronic heart failure (CHF), peripheral blood mononuclear cells (PBMC)
might undergo structural and/or functional alterations as a consequence of the development …

[HTML][HTML] Dynamic adaptation of myocardial proteome during heart failure development

J Rüdebusch, A Benkner, A Poesch, M Dörr, U Völker… - PLoS …, 2017 - journals.plos.org
Heart failure (HF) development is characterized by huge structural changes that are crucial
for disease progression. Analysis of time dependent global proteomic adaptations during HF …

[HTML][HTML] Multimarker proteomic profiling for the prediction of cardiovascular mortality in patients with chronic heart failure

G Lemesle, F Maury, O Beseme, L Ovart, P Amouyel… - PLoS …, 2015 - journals.plos.org
Risk stratification of patients with systolic chronic heart failure (HF) is critical to better identify
those who may benefit from invasive therapeutic strategies such as cardiac transplantation …

Physiological proteomics of heart failure

J O'Reilly, ML Lindsey, JA Baugh - Current Opinion in Physiology, 2018 - Elsevier
Highlights•The complex pathophysiology of heart failure is summarized.•This article reviews
the use of proteomics to elucidate responses to cardiac injury.•Proteomic analyses of tissue …

Global plasma protein profiling reveals DCM characteristic protein signatures

MA Feig, C Pop, G Bhardwaj, PK Sappa, M Dörr… - Journal of …, 2019 - Elsevier
To identify potential biomarkers supporting better phenotyping and to improve
understanding of the pathophysiology of dilated cardiomyopathy (DCM), this study …

[HTML][HTML] Plasma proteomic analysis of association between atrial fibrillation, coronary microvascular disease and heart failure

G Dixit, J Blair, C Ozcan - American Journal of Cardiovascular …, 2022 - ncbi.nlm.nih.gov
The clinical association between atrial fibrillation (AF), coronary microvascular disease
(CMD) and heart failure with preserved ejection fraction (HFpEF) is highly prevalent …

[HTML][HTML] Urinary proteomic signature in acute decompensated heart failure: advances into molecular pathophysiology

E Diaz-Riera, M García-Arguinzonis, L López… - International Journal of …, 2022 - mdpi.com
Acute decompensated heart failure (ADHF) is a life-threatening clinical syndrome involving
multi-organ function deterioration. ADHF results from multifaceted, dysregulated pathways …