B cells play important roles in normal immunity and human disease. While much has been
learned from elegant studies utilizing genetically modified mice or with immunotherapy in …

Autoreactive B cells are one of the key immune cells that have been implicated in the
pathogenesis of systemic lupus erythematosus (SLE). In addition to the production of …

Over the last several years, there has been marked interest regarding the role of B cells in
the pathogenesis of systemic lupus erythematosus (SLE) as well as multiple other …

B cell-depletion therapy, particularly using anti-CD20 treatment, has provided proof of
concept that targeting B cells and the humoral response may result in clinical improvements …

Systemic lupus erythematosus (SLE) is a chronic disabling autoimmune disease that
significantly impacts the quality of life of patients, and can associate with several …

B cells play a critical role in the pathogenesis of rheumatoid arthritis (RA) and other
autoimmune diseases. Recently, a number of biologic agents that target B cells have been …

Members of the B-lymphocyte stimulator (BLyS) family play key roles in B-lymphocyte
survival, selection, and differentiation. Recent US FDA approval of the neutralizing anti-BLyS …

Aberrant B cell signaling plays a critical in role in various systemic and organ-specific
autoimmune diseases. This is supported by genetic evidence by many functional studies in …

B-lymphocyte stimulator (BLyS), a homeostatic factor for B-cell differentiation and survival,
has a major role in B-cell expansion and autoreactivity that characterize systemic lupus …

B‐cell targeted therapies have enjoyed recent success in the treatment of systemic
autoimmune diseases. Among these, Belimumab, which blocks the B‐cell survival cytokine …