Brugada syndrome (BrS) is an inherited arrhythmogenic disease that may lead to sudden
cardiac death in young adults with structurally normal hearts. No pharmacological therapy is …

Background Evidence for the role of the CACNA1C gene, which encodes for the α-subunit of
the cardiac L-type calcium channel CaV1. 2, as a cause of the BrS3 variant of Brugada …

Background A loss of function of the L-type calcium channel, Cav1. 2, results in a cardiac
specific disease known as Brugada syndrome. Although many Brugada syndrome …

Background—Cardiac ion channelopathies are responsible for an ever-increasing number
and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that …

Recent studies have demonstrated an association between mutations in CACNA1c or
CACNB2b and Brugada syndrome (BrS). Previously described mutations all caused a loss …

Background The L-type calcium channel Cav1. 2 is important for brain and heart function.
The ubiquitous calcium sensing protein calmodulin (CaM) regulates calcium dependent …

Aims: Some gene variants in the sodium channels, as well as calcium channels, have been
associated with Brugada syndrome (BrS). However, the investigation of the human cellular …

Background Brugada syndrome (BrS) is an inherited cardiac arrhythmia associated with
sudden death due to ventricular fibrillation. Mutations in genes related to the cardiac L-type …

Brugada syndrome (BrS) is a relatively rare arrhythmia disorder that can lead to sudden
cardiac death (SCD) due to ventricular tachycardia/fibrillation (VT/VF), predominantly in …

Brugada syndrome (BrS) is characterized by ST-segment elevation in the right precordial
leads and is associated with increased risk of sudden cardiac death. We have recently …