Background & Aims T cells play a critical role in viral infection. We examined whether T-cell
effector and regulatory responses can define clinical stages of chronic hepatitis B (CHB) …

BACKGROUND & AIMS: Chronic hepatitis B (CHB) infection acquired perinatally or in early
childhood has been associated with a prolonged phase of immune tolerance from viral …

To assess the significance of cell-mediated immunity, T cells were derived from the
peripheral blood and liver tissue of hepatitis B virus (HBV)-infected patients and controls …

To identify immunological mechanisms that govern distinct clinical phases of a chronic
hepatitis B virus (HBV) infection—immune tolerant (IT), immune active (IA), inactive carrier …

Objective Hepatitis B virus (HBV)-specific T cells are main effector cells in the control of HBV
infection and hepatitis B surface antigen (HBsAg) is suggested to be a critical factor in the …

Background & Aims The role of hepatitis B virus (HBV)-specific CD4 T cells in patients with
chronic HBV infection is not clear. Thus, we aimed to elucidate this in patients with chronic …

Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

Background & Aims Chronic hepatitis B virus (HBV) infection is characterized by the
presence of defective viral envelope proteins (hepatitis B surface antigen [HBsAg]) and the …

Background & Aims Hepatitis B virus (HBV) persistence and the pathobiology of chronic
HBV (CHB) infections result from the interplay between viral replication and host immune …

Chronic hepatitis B (CHB) is a global health problem affecting more than 350 million people
worldwide. Chronic carriage of HBV is related to the age when the infection occurs; the …