Background: Depression is a heavily prevalent mental disorder. Symptoms of depression
extend beyond mood, cognition, and behavior to include a spectrum of somatic …

Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading
cause of disability, affecting approximately 100 million adults worldwide. The disorder is …

The clinical observations of diurnal variation of mood and early morning awakening in
depression have been incorporated into established diagnostic systems, as has the …

A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

There are two main reasons for the growing interest in the dependence of mood disorders
on the circadian clock and its connected pathways. First, the successful translation of …

Background A long-standing challenge in the treatment of depression is the development of
a rapidly acting antidepressant. Conventional antidepressants typically require 2–8 weeks …

Discoveries in the molecular genetics of the circadian clock and the introduction of the
antidepressant agent, agomelatine, with effects on circadian rhythms, have revived interest …

In humans almost all physiological and behavioural functions occur on a rhythmic basis.
Therefore the possibility that delays, advances or desynchronizations of circadian rhythms …

Objective The aim of this article is to review progress in understanding the mechanisms that
underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of …

Circadian rhythms are near 24-h cycles in a number of physiological and behavioural
parameters and the underpinning circadian timing systems is one of the key homeostatic …