Optical signatures of thermal damage on ex-vivo brain, lung and heart tissues using time-domain diffuse optical spectroscopy

A Bossi, L Bianchi, P Saccomandi… - Biomedical Optics …, 2024 - opg.optica.org
Thermal therapies treat tumors by means of heat, greatly reducing pain, post-operation
complications, and cost as compared to traditional methods. Yet, effective tools to avoid …

Temporal evolution of optical properties at different temperatures of biological tissues

A Bossi, L Bianchi, P Saccomandi… - … and Spectroscopy of …, 2023 - spiedigitallibrary.org
Thermal therapy is a minimally invasive technique with great potential for treating tumors in
non-surgical candidates. Minimally invasive procedures reduce post-operation …

Monitoring radiofrequency ablation of biological tissue using broadband time-resolved diffuse optical spectroscopy

P Lanka, KJ Francis, H Kruit, SKV Sekar… - … on Biomedical Optics, 2019 - opg.optica.org
Radiofrequency ablation (RFA) is minimally invasive thermotherapy, where a heating source
is used to target and kill malignant cells in a tissue. While RFA has tremendous potential in …

Characterization of the Optical and Thermal Properties of Cardiac Tissue as a Function of Temperature

L Bianchi, A Bossi, A Pifferi… - 2023 45th Annual …, 2023 - ieeexplore.ieee.org
In this work, we devised the first characterization of the optical and thermal properties of ex
vivo cardiac tissue as a function of different selected temperatures, ranging from room …

Non-invasive measurement of deep tissue temperature changes caused by apoptosis during breast cancer neoadjuvant chemotherapy: a case study

SH Chung, R Mehta, BJ Tromberg… - Journal of innovative …, 2011 - World Scientific
Treatment-induced apoptosis of cancer cells is one goal of cancer therapy. Interestingly,
more heat is generated by mitochondria during apoptosis, especially the uncoupled …

Optical signatures of radiofrequency ablation in biological tissues

P Lanka, KJ Francis, H Kruit, A Farina, R Cubeddu… - Scientific reports, 2021 - nature.com
Accurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in
oncology and cardiovascular disease. We investigated alterations in optical properties of ex …

Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues

VK Nagarajan, VR Gogineni, SB White… - International Journal of …, 2018 - Taylor & Francis
Complete ablation of liver tumors is vital for minimizing the risk of local tumor recurrence.
Accurately identifying the hallmarks of tissue necrosis during thermal ablative therapies may …

Assessment of tissue heating under tunable near-infrared radiation

JN Bixler, BH Hokr, ML Denton… - … of biomedical optics, 2014 - spiedigitallibrary.org
The time-temperature effects of laser radiation exposure are investigated as a function of
wavelength. Here, we report the thermal response of bulk tissue as a function of wavelength …

Diffuse near-infrared reflectance spectroscopy during heatstroke in a mouse model: pilot study

D Abookasis, E Zafrir, E Nesher… - … of biomedical optics, 2012 - spiedigitallibrary.org
Heatstroke, a form of hyperthermia, is a life-threatening condition characterized by an
elevated core body temperature that rises above 40° C (104° F) and central nervous system …

Application of spatially modulated near-infrared structured light to study changes in optical properties of mouse brain tissue during heatstress

O Shaul, M Fanrazi-Kahana, O Meitav, GA Pinhasi… - Applied Optics, 2017 - opg.optica.org
Heat stress (HS) is a medical emergency defined by abnormally elevated body temperature
that causes biochemical, physiological, and hematological changes. The goal of the present …