Hypertension is the leading cause of morbidity and mortality globally among all
cardiovascular diseases. Purinergic signalling plays a crucial role in hypertension through …

In the last two decades a tremendous development has been noticed in our understanding
of the purinergic system, consisting of heterogeneously expressed purinoceptor subtypes …

Highlights•Renal distribution of P2 purinoceptors in vascular, glomerular and tubular
structures.•P2 receptors are important for renal autoregulation and for regulation of renal …

Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining
normal blood pressure, kidney function and water and electrolyte homeostasis. The renal …

Purinergic G-protein-coupled receptors are ancient and the most abundant group of G-
protein-coupled receptors (GPCRs). The wide distribution of purinergic receptors in the …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

This review considers the expression and roles of P2X receptors in the cardiovascular
system in health and disease and their potential as therapeutic targets. P2X receptors are …

Atherosclerosis is the main pathological basis of cardiovascular disease and involves
damage to vascular endothelial cells (ECs) that results in endothelial dysfunction (ED). The …

In blood vessels, stimulation of the vascular endothelium by the Ca2+-mobilizing agonist
ATP initiates a number of cellular events that cause relaxation of the adjacent smooth …

The purine nucleotides and nucleosides constitute important extracellular signaling
molecules acting as neurotransmitters and neuromodulators. Indeed, extracellular …