Myocardial infarction (MI) is characterized by cardiac tissue death due to a lack of blood
delivery to the heart. Heart failure (HF) is one of the many complications caused by MI and …

Aims Myocardial infarction (MI) is a major cause of death. Nicotinamide adenine
dinucleotide (NAD+) is a coenzyme in oxidative phosphorylation and substrate of sirtuins …

Decreased nicotinamide adenine dinucleotide (NAD+) levels contribute to various
pathologies such as ageing, diabetes, heart failure and ischemia–reperfusion injury (IRI) …

Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As
the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for …

Purpose Low NAD+ levels are observed in pathologies such as ageing, diabetes, heart
failure and ischemia-reperfusion (IR) injury. Nicotinamide riboside (NR) has emerged as …

Objectives The co-primary objectives of this study were to determine the human
pharmacokinetics (PK) of oral NR and the effect of NR on whole blood nicotinamide adenine …

Nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for nicotinamide
adenine dinucleotide (NAD+) synthesis, and Sirt1, an NAD+-dependent histone …

Purpose Cardioprotective strategies against ischaemia-reperfusion injury (IRI) that remain
effective in the clinical arena need to be developed. Here, we examined the efficacy of the …

Introduction NAD+ is a key co-enzyme in energy metabolism and a signaling substrate used
by the sirtuins and poly (ADPribose) polymerases (PARPs), regulating energy metabolism …

Nicotinamide adenine dinucleotide (NAD) is an abundant cofactor that plays crucial roles in
several cellular processes. NAD can be synthesized de novo starting with tryptophan, or …