Insights into ocular therapeutics: a comprehensive review of anatomy, barriers, diseases and nanoscale formulations for targeted drug delivery

A Chandel, G Kandav - Journal of Drug Delivery Science and Technology, 2024 - Elsevier
Ocular drug delivery systems play a critical role in the treatment of various eye diseases via
ensuring targeted and efficient delivery of therapeutic agent. The complex anatomy and …

How are we improving the delivery to back of the eye? Advances and challenges of novel therapeutic approaches

V Agrahari, V Agrahari, A Mandal, D Pal… - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Drug delivery to the back of the eye requires strategic approaches that
guarantee the long-term therapeutic effect with patient compliance. Current treatments for …

Nano-based ocular drug delivery systems: an insight into the preclinical/clinical studies and their potential in the treatment of posterior ocular diseases

Y Su, X Fan, Y Pang - Biomaterials Science, 2023 - pubs.rsc.org
Numerous novel nano-based ocular drug delivery systems have been developed to
overcome the limitations of conventional drug delivery systems, which have demonstrated …

ISOPT Clinical Hot Topic Panel Discussion on Ocular Drug Delivery

UB Kompella, A Domb, A Urtti, A Jayagopal… - Journal of Ocular …, 2019 - liebertpub.com
Ocular drug delivery offers unique challenges and opportunities in the era of novel
therapeutic agents ranging from small molecules to gene therapies. Noninvasive delivery of …

Drug delivery to the eye: what benefits do nanocarriers offer?

RR Joseph, SS Venkatraman - Nanomedicine, 2017 - Future Medicine
Ocular drug delivery has seen several advances in the past few decades, with respect to
new drugs, improved formulations, targeted delivery, as well as exploration of new routes of …

Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

When nanotechnology meets the ocular surface

C Bucolo, A Maltese, F Drago - Expert Review of Ophthalmology, 2008 - Taylor & Francis
Controlled and sustained delivery of drugs for ophthalmic diseases continues to remain a
major challenge in the field of pharmaceutical drug delivery. To overcome the problems of …

Noninvasive ocular drug delivery: potential transcorneal and other alternative delivery routes for therapeutic molecules in glaucoma

M Foldvari - Journal of Glaucoma, 2014 - journals.lww.com
Drug delivery to the eye is made difficult by multiple barriers (such as the tear film, cornea,
and vitreous) between the surface of the eye and the treatment site. These barriers are …

Drug delivery systems for the eye

VR Kearns, RL Williams - Expert Review of Medical Devices, 2009 - Taylor & Francis
Topical and systemic administration of drugs to the eye is highly inefficient and there is a
need for controlled, sustained release, particularly for conditions that affect the posterior …

Ocular implants–a novel approach in ocular drug delivery

S Kiss, J Pena - Recent Patents on Nanomedicine, 2012 - ingentaconnect.com
The applications for ocular implants are as broad as the pathology of eye. The success of
treating ophthalmologic disease will be enhanced by targeted and sustained drug delivery …