A gut microbiome metabolite paradoxically depresses contractile function while activating mitochondrial respiration
ABSTRACT Trimethylamine-N-oxide (TMAO) is an end-product of gut microbiome
metabolism linked to cardiovascular disease (CVD). However, precise cardiovascular …
metabolism linked to cardiovascular disease (CVD). However, precise cardiovascular …
Microbiome, trimethylamine N-oxide, and cardiometabolic disease
There is increasing appreciation that changes in microbiome composition and function can
promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites …
promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites …
The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases
J Zhen, Z Zhou, M He, HX Han, EH Lv… - Frontiers in …, 2023 - frontiersin.org
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …
Researchers have found that the occurrence and development of CVDs are closely related …
Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure
Background Patients at increased risk for coronary artery disease and adverse prognosis
during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a …
during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a …
Microbiota-derived metabolite trimethylamine N-oxide protects mitochondrial energy metabolism and cardiac functionality in a rat model of right ventricle heart failure
M Videja, R Vilskersts, S Korzh, H Cirule… - Frontiers in cell and …, 2021 - frontiersin.org
Aim: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite synthesized in
host organisms from specific food constituents, such as choline, carnitine and betaine …
host organisms from specific food constituents, such as choline, carnitine and betaine …
[HTML][HTML] TMAO: how gut microbiota contributes to heart failure
Y Zhang, Y Wang, B Ke, J Du - Translational Research, 2021 - Elsevier
An increasing amount of evidence reveals that the gut microbiota is involved in the
pathogenesis and progression of various cardiovascular diseases. In patients with heart …
pathogenesis and progression of various cardiovascular diseases. In patients with heart …
Unraveling the Complex Relationship Between Gut Microbiome and Cardiovascular Diseases
Meanwhile, the contributions of structurally specific gut microbiota-generated metabolites to
cardiovascular and metabolic health have emerged as a multifaceted area of research with …
cardiovascular and metabolic health have emerged as a multifaceted area of research with …
Gut microbiota-dependent metabolite trimethylamine N-oxide contributes to cardiac dysfunction in western diet-induced obese mice
K Chen, X Zheng, M Feng, D Li, H Zhang - Frontiers in physiology, 2017 - frontiersin.org
Excessive consumption of diets high in sugars and saturated fat, frequently known as
western diet (WD), may lead to obesity and metabolic syndrome. Recent evidence shows …
western diet (WD), may lead to obesity and metabolic syndrome. Recent evidence shows …
[HTML][HTML] Trimethylamine N-oxide in cardiovascular disease
RA Konieczny, W Kuliczkowski - Advances in Clinical and …, 2022 - advances.umw.edu.pl
Although traditional cardiovascular risk factors are well established and understood,
mortality and morbidity in patients with cardiovascular disease (CVD) remains high …
mortality and morbidity in patients with cardiovascular disease (CVD) remains high …
Prognostic value of elevated levels of intestinal microflora-generated metabolite trimethylamine n-oxide in patients with heart failure: The gut hypothesis revisited
Background Accumulation of intestinal microbial-dependent dietary phosphatidylcholine
metabolite, trimethylamine N-oxide (TMAO), has been associated with coronary artery …
metabolite, trimethylamine N-oxide (TMAO), has been associated with coronary artery …