Although melatonin is an astonishing molecule, it is possible that chemistry will help in the
discovery of new compounds derived from it that may exceed our expectations regarding …

Melatonin is a neurohormone produced in the pineal gland that regulates circadian
rhythmicity, with maximal secretion at night. The natural decline of melatonin levels with age …

Melatonin is an indoleamine produced mainly in the pineal gland. The natural decline of
melatonin levels with aging strongly contributes to the development of neurodegenerative …

Melatonin is known for its radical scavenger activity, which is related to its ability to protect
cells from different kinds of oxidative stress. Oxidative stress has been implicated in the …

A set of 19 melatonin analogues, intended to be better antioxidants than the parent
molecule, have been computationally designed. Eight of them were planned to have good …

A systematic rational search for newly designed melatonin derivatives, was performed using
a computer-assisted protocol. A total of 116 derivatives were generated by adding functional …

Oxidative stress has been reported to be involved in the onset and development of several
diseases, including neurodegenerative and cardiovascular disorders, some types of cancer …

Melatonin is an uncommonly widely distributed molecule. It is found throughout the plant
and animal kingdoms, ie, perhaps in every living organism. Within vertebrate organisms …

It is known that melatonin (MLT) and some of its metabolites act as antioxidants by
scavenging free radicals as well as increasing the activity of antioxidant enzymes in the …

Aging is associated with increasing impairments in brain homeostasis and represents the
main risk factor across most neurodegenerative disorders. Melatonin, a neuroendocrine …