Reverse transcription in HIV-1 is initiated from an intermolecular template: primer duplex
formed by annealing of the U5-primer binding site (U5-PBS) region of the HIV genome with …

HIV-1 reverse transcriptase (RT) utilizes RNA oligomers to prime DNA synthesis. The
initiation of reverse transcription requires specific interactions between HIV-1 RNA, primer …

Initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription requires
specific recognition between the viral RNA (vRNA), tRNA 3 Lys, which acts as primer, and …

HIV-1 reverse transcription is initiated from a tRNA 3 Lys molecule annealed to the viral RNA
at the primer binding site (PBS), but the structure of the initiation complex of reverse …

Initiation of human immunodeficiency virus type 1 (HIV‐1) reverse transcription requires
specific recognition of the viral genome, tRNA 3 Lys, which acts as primer, and reverse …

A hallmark of the initiation step of HIV-1 reverse transcription, in which viral RNA genome is
converted into double-stranded DNA, is that it is slow and non-processive. Biochemical …

The initiation of reverse transcription in human immunodeficiency virus-1 is a key early step
in the virus replication cycle. During this process, the viral enzyme reverse transcriptase (RT) …

Retroviruses use a specific tRNA, whose 3′ end is complementary to the 18 nucleotides of
the primer binding site (PBS), to prime reverse transcription. Previous work has shown that …

The initiation phase of HIV reverse transcription has features that are distinct from its
elongation phase. The first structure of a reverse transcription initiation complex (RTIC) that …

Reverse transcription of the HIV-1 RNA genome into double-stranded DNA is a central step
in infection and a common target of anti-retrovirals. The reaction is catalyzed by viral enzyme …