Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

R Bai, J Guo, XY Ye, Y Xie, T Xie - Ageing research reviews, 2022 - Elsevier
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

Oxidative stress in Alzheimer's disease

Z Chen, C Zhong - Neuroscience bulletin, 2014 - Springer
Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a
devastating disease of the elderly. The brain is more vulnerable than other organs to …

Oxidative stress and the pathogenesis of Alzheimer′ s disease

Y Zhao, B Zhao - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …

Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms

R Von Bernhardi, J Eugenín - Antioxidants & redox signaling, 2012 - liebertpub.com
Alzheimer's disease (AD) is the most common cause of dementia and a progressive
neurodegeneration that appears to result from multiple pathogenic mechanisms (including …

Oxidative stress in Alzheimer's disease

V Chauhan, A Chauhan - Pathophysiology, 2006 - Elsevier
Oxidative damage is a major feature in the pathophysiology of Alzheimer's disease (AD). In
this review, we discuss free radical-mediated damage to the biochemical components …

Oxidative stress in Alzheimer's disease: implications for prevention and therapy

C Behl - Alzheimer's Disease: Cellular and Molecular Aspects of …, 2005 - Springer
Oxidative stress is a marker of neurodegeneration and has been recently shown to be also
involved in the early stages of the pathogenesis of various neurodegenerative disorders. In …

Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer's disease

G Plascencia-Villa, G Perry - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a brain disorder that progressively undermines memory and
thinking skills by affecting the hippocampus and entorhinal cortex. The main …

Oxidative stress hypothesis in Alzheimer's disease

WR Markesbery - Free radical biology and medicine, 1997 - Elsevier
The major hurdle in understanding Alzheimer's disease (AD) is a lack of knowledge about
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …

Oxidative stress and beta amyloid in Alzheimer's disease. Which comes first: the chicken or the egg?

E Tamagno, M Guglielmotto, V Vasciaveo, M Tabaton - Antioxidants, 2021 - mdpi.com
The pathogenesis of Alzheimer's disease involves β amyloid (Aβ) accumulation known to
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …

Alzheimer disease and oxidative stress

G Perry, AD Cash, MA Smith - BioMed Research International, 2002 - Wiley Online Library
Research in Alzheimer disease has recently demonstrated compelling evidence on the
importance of oxidative processes in its pathogenesis. Cellular changes show that oxidative …