Animal fetuses may be used for the regeneration of human organs. We have previously
generated a transgenic mouse model that allows diphtheria toxin (DT)-induced ablation of …

Animal fetuses and embryos may have applications in the generation of human organs.
Progenitor cells may be an appropriate cell source for regenerative organs because of their …

Kidney regeneration is expected to be a new alternative treatment to the currently limited
treatments for chronic kidney disease. By transplanting exogeneous nephron progenitor …

Generation of kidney organoids from pluripotent stem cells (PSCs) is regarded as a
potentially powerful way to study kidney development, disease, and regeneration. Direct …

Chronic kidney disease (CKD) is a worldwide health care problem, resulting in increased
cardiovascular mortality and often leading to end-stage kidney disease, where patients …

It has been a challenge in developmental biology and regenerative medicine to generate
nephron progenitors that reconstitute the three-dimensional (3D) nephron structure in vitro …

Kidney regenerative medicine is expected to be the solution to the shortage of organs for
transplantation. In a previous report, we transplanted exogenous renal progenitor cells …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …

The kidney is an important organ for maintenance of homeostasis in the human body. As
renal failure progresses, renal replacement therapy becomes necessary. However, there is …

Embryonic stem cells and induced pluripotent stem cells have the ability to differentiate into
various organs and tissues, and are regarded as new tools for the elucidation of disease …