Conspectus Electron microscopy (EM) is the most versatile tool for the study of matter at
scales ranging from subatomic to visible. The high vacuum environment and the charged …

Microscopy: Cryo-EM enters a new era | eLife Skip to Content eLife logo eLife home page Menu
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Transmission electron microscopy (EM) is a versatile technique that can be used to image
biological specimens ranging from intact eukaryotic cells to individual proteins> 150 kDa …

The three-dimensional structure of biological macromolecules, such as proteins and nucleic
acids, and their complexes is the fundamental information not only for life sciences but also …

All steps of cryogenic electron-microscopy (cryo-EM) workflows have rapidly evolved over
the last decade. Advances in both single-particle analysis (SPA) cryo-EM and cryo-electron …

Structural Biology: Direct detection pays off for electron cryo-microscopy | eLife Skip to Content
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Cryo-electron microscopy (cryo-EM) is a powerful tool for macromolecular to near-atomic
resolution structure determination in the biological sciences. The specimen is maintained in …

Macromolecular imaging and tomography of ice embedded samples has developed into a
mature imaging technology, in structural biology today widely referred to simply as cryo …

Conspectus Cryogenic-temperature transmission electron microscopy (cryo-TEM) of
aqueous systems has become a widely used methodology, especially in the study of …

Abstract The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim
Frank, and Richard Henderson for “developing cryo-electron microscopy (cryo-EM) for the …