Abstract C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1)
gene have substantial impact on expression or activity of P‐glycoprotein (P‐gp). We …

P-Glycoprotein (PGP) encoded by the multi-drug-resistance 1 (MDR1) gene is a member of
theATP-binding cassette (ABC) transporter family, drug-transporting proteins involved in the …

The objective of this study was to develop a real-time polymerase chain reaction (PCR)
method to detect MDR1 (human multidrug resistance gene) single nucleotide …

We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in
exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese …

In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

Two representative genetic variants of the MDR1 gene, 3435C> T and 2677G> T/A, show
wide interethnic differences in its genetic polymorphism. In this study, the authors evaluated …

The human multidrug-resistant gene (MDR1) encodes for P-glycoprotein (P-gp), which is a
membrane-bound effluxtransporter conferring resistance to a number of natural cytotoxic …

OBJECTIVES: To investigate the genetic variability of multiple drug resistant 1 (MDR1) gene
C3435T polymorphism in four Southern Chinese populations. METHODS: Using …

OBJECTIVES: P-glycoprotein (P-gp) is significant from the viewpoint of pharmacokinetics/
pharmacodynamics (PK/PD). MDR1 gene encodes P-gp and has a wide variety of SNPs. As …

The aim of this study was to perform the frequency distribution of MDR1 gene SNPs and
haplotypes of Jiangsu Han population in China. A total of 225 Jiangsu Han unrelated …