Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Background Addiction health service researchers have focused efforts on opioid use
disorder (OUD) and strategies to address the emerging public health threats associated with …

ABSTRACT Introduction: Opioid Use Disorder (OUD) is a significant public health concern,
negatively impacting the medical, psychological, and social domains of an individual's life as …

Background and Objectives The opioid crisis has taken an immense toll in the United States.
On average, five lives are lost to an opioid overdose every hour of the day; estimated costs …

Opioid use disorder is highly prevalent and can be fatal. At least 2.1 million Americans 12
years and older had opioid use disorder in 2016, and approximately 47,000 Americans died …

Amid worsening opioid overdose death rates, the nation continues to face a persistent
addiction treatment gap limiting access to quality care for opioid use disorder (OUD). Three …

The opioid crisis in the United States has come about because of excessive use of these
drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use …

Objective: Opioid use disorder (OUD) in the United States has surged, with an estimated 2.5
million needing treatment. The aim of this article is to provide a clinical overview of the key …

The opioid crisis in the United States has come about because of excessive use of these
drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use …

Importance More than 42 000 Americans died of opioid overdoses in 2016, and the fatalities
continue to increase. This review analyzes the factors that triggered the opioid crisis and its …