Metabolic diseases (eg., obesity and type 2 diabetes) along with their serious sequelae such
as non-alcoholic fatty liver disease (NAFLD) have reached epidemic proportions in the …

Skeletal muscle is a major determinant of systemic metabolic homeostasis that plays a
critical role in glucose metabolism and insulin sensitivity. By contrast, despite being a major …

Skeletal muscle dynamically regulates systemic nutrient homeostasis through transcriptional
adaptations to physiological cues. In response to changes in the metabolic environment (eg …

Adipose tissue stores energy in the form of triglycerides. The ability to regulate triglyceride
synthesis and breakdown based on nutrient status (eg, fed versus fasted) is critical for …

Metabolic syndrome (MetSyn) is a combination of metabolic abnormalities that lead to the
development of cardiovascular disease (CVD) and Type 2 Diabetes (T2D). Although various …

Human genetic studies have identified DNA variants near the KLF14 gene to be strongly
associated with HDL cholesterol levels, triglyceride levels, risk of type 2 diabetes mellitus …

The ability of skeletal muscle to enhance lipid utilization during exercise is a form of
metabolic plasticity essential for survival. Conversely, metabolic inflexibility in muscle can …

Abstract Objective The transcription factor Krüppel-like factor 14 (KLF14) has been
associated with type 2 diabetes and high-density lipoprotein-cholesterol (HDL-C) through …

Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that
regulate various pathways that control metabolism and other cellular mechanisms. Various …

Substantial evidence implicates crosstalk between metabolic tissues and the immune
system in the inception and progression of obesity. However, molecular regulators that …