Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype
JG Thöming, J Tomasch, M Preusse, M Koska… - npj Biofilms and …, 2020 - nature.com
Studying parallel evolution of similar traits in independent within-species lineages provides
an opportunity to address evolutionary predictability of molecular changes underlying …
an opportunity to address evolutionary predictability of molecular changes underlying …
Genetic determinants of Pseudomonas aeruginosa biofilm establishment
The establishment of bacterial biofilms on surfaces is a complex process that requires
various factors for each consecutive developmental step. Here we report the screening of …
various factors for each consecutive developmental step. Here we report the screening of …
A previously uncharacterized gene, PA2146, contributes to biofilm formation and drug tolerance across the ɣ-Proteobacteria
MF Kaleta, OE Petrova, C Zampaloni… - npj Biofilms and …, 2022 - nature.com
Transcriptomic studies have revealed a large number of uncharacterized genes that are
differentially expressed in biofilms, which may be important in regulating biofilm phenotypes …
differentially expressed in biofilms, which may be important in regulating biofilm phenotypes …
Temperature-specific adaptations and genetic requirements in a biofilm formed by Pseudomonas aeruginosa
Pseudomonas aeruginosa is a gram-negative opportunistic pathogen often associated with
nosocomial infections that are made more severe by this bacterium's ability to form robust …
nosocomial infections that are made more severe by this bacterium's ability to form robust …
[HTML][HTML] Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth
S Schinner, F Engelhardt, M Preusse, JG Thöming… - Biofilm, 2020 - Elsevier
Pseudomonas aeruginosa is an environmental bacterium and an opportunistic human
pathogen. It is also a well-established model organism to study bacterial adaptation to …
pathogen. It is also a well-established model organism to study bacterial adaptation to …
The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates
J Erdmann, JG Thöming, S Pohl, A Pich, C Lenz… - Cells, 2019 - mdpi.com
Comparative genomics has greatly facilitated the identification of shared as well as unique
features among individual cells or tissues, and thus offers the potential to find disease …
features among individual cells or tissues, and thus offers the potential to find disease …
An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1
AR Varadarajan, RN Allan, JDP Valentin… - npj Biofilms and …, 2020 - nature.com
Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon
mutant collection for this important clinical pathogen. Here, we validate a model system to …
mutant collection for this important clinical pathogen. Here, we validate a model system to …
Spatial transcriptomes within the Pseudomonas aeruginosa biofilm architecture
Y Heacock‐Kang, Z Sun, J Zarzycki‐Siek… - Molecular …, 2017 - Wiley Online Library
Bacterial cooperative associations and dynamics in biofilm microenvironments are of special
interest in recent years. Knowledge of localized gene‐expression and corresponding …
interest in recent years. Knowledge of localized gene‐expression and corresponding …
Fitness Landscape of Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms
S Amini, AK Hottes, LE Smith, S Tavazoie - PLoS pathogens, 2011 - journals.plos.org
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A
major outstanding question is the degree to which the biofilm-specific cellular state and its …
major outstanding question is the degree to which the biofilm-specific cellular state and its …
Strain-specific parallel evolution drives short-term diversification during Pseudomonas aeruginosa biofilm formation
KE McElroy, JGK Hui, JKK Woo… - Proceedings of the …, 2014 - National Acad Sciences
Generation of genetic diversity is a prerequisite for bacterial evolution and adaptation. Short-
term diversification and selection within populations is, however, largely uncharacterised, as …
term diversification and selection within populations is, however, largely uncharacterised, as …