Subcutaneous and pulmonary insulin is associated with medical and pharmaceutical
complications. Oral insulin mimics physiological glucose regulation with reduced …

Oral delivery of insulin-loaded therapeutics is challenging due to the extreme pH condition,
enzymatic degradation, and limited permeation in the gastrointestinal (GI) tract …

Diabetes is a chronic metabolic disease characterized by lack of insulin in the body leading
to failure of blood glucose regulation. Diabetes patients usually need frequent insulin …

The development of orally administered protein drugs is challenging due to their intrinsic
unfavourable features, including large molecular size and poor chemical stability, both of …

Success in the oral delivery of therapeutic insulin can significantly improve the quality of life
of diabetic patients who must routinely receive injections of this drug. However, oral …

Although nanoparticles (NPs) have been used for many drug delivery applications, oral
absorption of NPs has remained a big challenge. NPs for oral delivery of biotherapeutics …

Oral delivery of insulin could widely improve the quality of life of diabetic patients but still
requires further exploration. Commonly utilized oral delivery vehicles hardly penetrate the …

Aim: To develop a novel nanocarrier with mucoadhesion and enzymatic inhibition for
transnasal insulin delivery. Methods & methods: The physicochemical characterization of the …

Mucoadhesive and mucopenetrating nanoparticles are commonly designed to improve
mucosal drug delivery efficiency. Herein, in order to better understand the contribution of …

Diabetes mellitus is one of the most serious public health problems in the world. Repeated
daily injections of subcutaneous insulin is the standard treatment for patients with type 1 …