Tuberculosis is a disease of global importance for which novel drugs are urgently required.
We developed a whole-cell phenotypic screen which can be used to identify inhibitors of …

We performed a high-throughput phenotypic whole cell screen of Mycobacterium
tuberculosis against a diverse chemical library of approximately 100,000 compounds from …

Tuberculosis is a serious global health problem caused by the bacterium Mycobacterium
tuberculosis. There is an urgent need for discovery and development of new treatments, but …

Despite the urgent need for new antitubercular drugs, few are on the horizon. To combat the
problem of emerging drug resistance, structurally unique chemical entities that inhibit new …

Here we describe the development and validation of an intracellular high-throughput
screening assay for finding new antituberculosis compounds active in human macrophages …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a leading cause of
morbidity and mortality worldwide. With the increased spread of multi drug-resistant TB …

Drug resistance in Mycobacterium tuberculosis is an emerging threat that makes the
discovery of new candidate drugs a priority. In particular, drugs with high sterilizing activity …

Increasing multidrug resistance in Mycobacterium tuberculosis continues to diminish the
number of effective drugs available for treatment of active tuberculosis. Although there are …

Mycobacterium tuberculosis is an important global pathogen for which new drugs are
urgently required. The ability of the organism to survive and multiply within macrophages …

In drug development, there are typically a series of preclinical studies that must be
completed with new compounds or regimens before use in humans. A sequence of in vitro …