Background Specific immunotherapy with whole allergen extracts is associated with local
accumulation of IFN‐γ+ and CD25+ cells indicating recruitment of activated T‐helper type 1 …

Background: Cells producing a Th2-cytokine profile play an important role in the onset and
maintenance of atopic diseases, and therefore specific immunotherapy is aimed to induce a …

Background: We previously showed that overlapping Fel d 1‐derived T‐cell peptides
inhibited surrogate markers of allergy (ie early and late‐phase skin reactions and T‐cell …

Intradermal administration of short overlapping peptides derived from chain 1 of the cat
allergen Fel d 1 (FC1P) that did not cross-link IgE, elicited isolated late asthmatic reactions …

Background: We have previously described both modification of allergen immunotherapy
using peptide fragments, and reduced regulation of allergen stimulated T cells by CD4+ …

Background Some patients with asthma who are allergic to cats and are injected
intradermally with short, overlapping, T-cell peptides derived from Fel d 1 develop late …

Background: In general, T cells from normal, nonatopic individuals respond to aeroallergens
with synthesis and release of IFN-γ. In contrast, release of TH2-type cytokines by activated …

Background: Peptide therapy targets T cells directly with short peptides containing multiple T-
cell receptor epitopes. Murine studies suggest T-cell anergy as the mechanism of action; …

BACKGROUND: Induction of CD4+ T cells that produce IL-10 or IFN-γ is central to the
protective effects of conventional allergen immunotherapy. OBJECTIVE: We examined the T …

We tested peptide immunotherapy in cat-allergic humans, using a formulation of two
synthetic peptides, IPC-1 and IPC-2, each of which is 27 amino acids long and contains T …